Memoir

What is being studied

Memantine and Graded Motor Imagery for Complex Regional Pain Syndrome (MEMOIR) 

MEMOIR is an Australian government-funded clinical trial testing two potential treatments for people with Complex Regional Pain Syndrome (CRPS): a medication (memantine) and a newly developed rehabilitation program (graded motor imagery). There are currently no treatments for CRPS supported by high-quality evidence. MEMOIR aims to test whether these interventions can reduce pain and improve function. 

About the trial

CRPS is a disabling pain disorder that typically occurs in a limb following tissue injury. It is characterised by severe burning, stinging and stabbing pain that is difficult to predict or control, and affects approximately 5,000 Australians each year. 

Participation

Screening steps: 

• Expression of interest 

• Eligibility check against study criteria (conducted by the study team and trial doctor, reviewing current treatments) 

What does participation involve (post-screening):

Group allocation: Randomised into one of four groups (2×2 factorial design): memantine + rehabilitation program / memantine + usual care / placebo + rehabilitation program / placebo + usual care. 

Duration: 16 weeks treatment + follow-up to 12 months. 

Sessions: Participants receiving the rehabilitation program attend 7 × 60-minute sessions via Zoom, plus guided daily activities for 16 weeks.

Assessment points: 4 questionnaire time points (approx. 20–30 min each) — baseline, end of treatment, 6 months, 12 months.

All participants take an oral study medicine or placebo for 16 weeks and maintain daily dose records.

Delivery

Fully remote via telehealth — no travel required, all activities completed from home.

Treatment duration

16-week treatment period, with follow-up assessments at 6 and 12 months

Age/eligibility

Adults aged 18 years and over, diagnosed with CRPS in one limb

Number of participants

204

Location

Margarete Ainsworth Building
Barker Street
Randwick NSW 2031

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